Duodenum is the most common site for diverticular disease of small intestine. Most of duodenal diverticula are asymptomatic or have non-specific upper gastrointestinal symptoms. The complications of duodenal diverticula depend on the location and include acute diverticulitis, perforation, hemorrhage, and obstruction of the biliary or pancreatic ducts. Duodenal diverticulum can be diagnosed with upper gastrointestinal endoscopy or radiographic series.

In this article, we present a case report of a large duodenal diverticulum, treated with laparoscopic surgical resection. After an accurate diagnosis; treatment modality should be determined by its localization, type and size. Laparotomy is the gold standard surgical treatment of complicated duodenal diverticular disease.

For laterally localized and protruded duodenal diverticula, laparoscopic resection is a feasible and safe method. The role of laparoscopy in surgical treatment of complicated diverticula, located in other parts of the duodenum, is unclear because of lack of experience.