en Sleeve Gastrectomy Sleeve Gastrectomy Original Original <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Background: Despite the improvement in health, function and quality of life of patients with morbid obesity following bariatric surgery, such intervention may result in some potential complications such as metabolic disturbances especially involving bone motabolism. The aim of this study was to evaluate the extent of Bone Mineral Density (BMD) changes in older patients with morbid obesity and its relation with bone metabolism indices.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Methods: This study was a single-center cross-sectional study on 50 new morbidly obese patients over 50 years old of age who were candidates for bariatric surgery. Before and 6 months after surgery, the values of BMD, anthropometric indices and metabolic serum biomarkers were assessed. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Results: BMD examination before and 6 months after surgery showed decrease in the BMD in hip region from </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">1.242 &plusmn; 0.136 to 1.117 &plusmn; 0.112 g/cm2, in the femoral neck from 1.109 &plusmn; 0.131 to 0.987 &plusmn; 0.127 g/cm2, in the lumbar spine from 1.253 &plusmn; 0.146 to 1.190 &plusmn; 0.135 g/cm2. </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">The analysis of BMD changes showed significant decrease in the bone density of all site measurement but with variable amounts. The decrement of BMD in the hip and femoral neck was significant but in the spine was not significant. The analysis on bone metabolism markers showed significant increase in </span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">25-Hydroxy vitamin D and </span></span></span><span style="font-size:12.0pt"><span style="background:white"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><span style="color:#202124">Alkaline phosphatase levels but decrease in</span></span></span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> calcium and parathyroid hormone (</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">PTH</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">) during 6 month follow up.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> There is significant decrease in BMD at various skeletal areas including femoral neck and hip region. Such changes can be in line with the changes in some serum metabolic and hormonal biomarkers such as calcium, PTH, vitamin D and alkaline phosphatase. </span></span></span>&nbsp;<span style="font-size:12.0pt"><span style="line-height:200%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span> sleeve gastrectomy, bone mineral density, calcium, vitamin D, parathyroid hormone, metabolism 93 98 http://annbsurg.iums.ac.ir/browse.php?a_code=A-10-61-4&slc_lang=en&sid=1 Nasser Malekpour Alamdari nassermalekpour@gmail.com 10031947532846002120 10031947532846002120 No Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Clinical Research Development Center, Shahid Modarres Educational hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Adel Zeinalpour adel.zeinalpour@gmail.com 10031947532846002121 10031947532846002121 No Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Clinical Research Development Center, Shahid Modarres Educational hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Forough hosseinipour forough.hosseeinipour@gmail.com 10031947532846002122 10031947532846002122 No Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Clinical Research Development Center, Shahid Modarres Educational hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fereshteh Kimia ferkimia@gmail.com 10031947532846002123 10031947532846002123 No Department of anesthesiology, labbafinezhad hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. barmak gholizadeh barmak.gholizadeh@gmail.com 10031947532846002124 10031947532846002124 Yes Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Clinical Research Development Center, Shahid Modarres Educational hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.