en MIS MIS Original Original Background: Surgeon&rsquo;s depend to a large degree on the amount of blood loss and a clear<br> view of the surgical field, when conducting endoscopic procedures in order to achieve<br> satisfactory outcomes. The anesthesiologist&rsquo;s choice of method for the induction and<br> maintenance of anesthesia plays a major role in achieving this goal.<br> Objectives: This study was performed in order to compare the two most well-known<br> methods in this regard; total intravenous anesthesia (TIVA) and venous inhalational<br> mixed anesthesia (VIMA).<br> Patients and Methods: This study included the endoscopic management of 89 patients<br> with cerebrospinal leakage (CSF leakage) covering a period of nine years (1999-2008) for<br> whom a subarachnoid injection of fluorescein was first administered, and afterwards<br> they were maintained under general anesthesia using two distinct methods; propofolremifentanil<br> versus isoflurane&ndash;remifentanil (inhalational or intravenous). During the<br> operation, hemodynamic indices, blood loss, and surgeon&rsquo;s satisfaction, were assessed<br> and compared between the two groups.<br> Results: Endoscopic management and autografts were successful in repairing anterior<br> skull defects in 90% of cases. Regarding the surgeon&rsquo;s satisfaction level, and hemodynamic<br> stability no significant difference between the two groups was observed (P > 0.01).<br> Conclusions: Both isoflurane and propofol in combination with remifentanil afford optimal<br> surgical conditions with regard to hemodynamic parameters and the satisfaction<br> of the surgeon with the surgical field. Cerebrospinal Fluid Propofol Remifentanil Isoflurane Endoscopy 0 0 http://annbsurg.iums.ac.ir/browse.php?a_code=A-10-31-238&slc_lang=en&sid=1 Valliolah Hassani 1003194753284600770 1003194753284600770 No 1 Department of Anesthesiology, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Mahzad Alimian 1003194753284600771 1003194753284600771 Yes 1 Department of Anesthesiology, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Mohammad Farhadi 1003194753284600772 1003194753284600772 No 1 Department of Anesthesiology, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Behrouz Zaman 1003194753284600773 1003194753284600773 No 1 Department of Anesthesiology, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Masood Mohseni 1003194753284600774 1003194753284600774 No 1 Department of Anesthesiology, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, IR Iran