en MIS MIS Original Original Background: Postoperative nausea and vomiting (PONV) is a frequent and unpleasant adverse<br> event associated with surgery. The reported incidence of PONV after laparoscopic<br> cholecystectomy (LC) is quite high. Despite the use of different drugs to prevent or relieve<br> PONV, it continues to be undermanaged. Recently, studies have been undertaken to determine<br> if gabapentin can be useful for the prevention of PONV.<br> Objectives: We assessed the effect of perioperative gabapentin administration on PONV<br> after LC.<br> Patients and Methods: We enrolled 92 patients scheduled to undergo LC for a randomized<br> double-blind placebo-controlled study. Patients were divided into two groups of 46 patients.<br> The intervention group received two doses of 600 mg gabapentin: one dose two hours before<br> surgery and one dose six hours after surgery. Similarly Control group received capsules<br> in the same size and shape as gabapentin capsules. All Patients were observed for PONV and<br> adverse effects of the drug for 24 h. Metoclopramid (10 mg) was used as the antiemetic in<br> patients with severe PONV in necessary circumstances. Total metoclopramid consumption<br> were recorded.<br> Results: There were no demographic differences between the 2 study groups. Within 24 h<br> of LC, 12 patients who received gabapentin (26.1%) and 30 patients who received a placebo<br> (65.2%) experienced nausea (P < 0.001), while 10 patients in the intervention group (21.7%)<br> and 24 patients in the control group (52.3%) vomited (P = 0.002). Metoclopramid was used<br> to control PONV in 11 intervention patients (23.9%) and 29 control patients (63%; P = 0.001).<br> Conclusions: Perioperative administration of gabapentin significantly decreases the incidence<br> of PONV and the requirement for postoperative antiemetic treatment following LC. Gabapentin Postoperative Nausea and Vomiting Cholecystectomy Laparoscopy 0 0 http://annbsurg.iums.ac.ir/browse.php?a_code=A-10-31-234&slc_lang=en&sid=1 Zhamak Khorgami 1003194753284600733 1003194753284600733 Yes 1 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Ahmadreza Soroush 1003194753284600734 1003194753284600734 No 1 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Hosein Masoomi 1003194753284600735 1003194753284600735 No 1 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Seyed Mojtaba Marashi 1003194753284600736 1003194753284600736 No 2 Department of Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Roza Mofid 1003194753284600737 1003194753284600737 No 1 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran