en Efficacy of Diclofenac Rectal Suppository in Patients with Laparoscopic Cholecystectomy: A Prospective Randomized Double Blinded Clinical Trial Basic Science Basic Science Original Original <sec> <div>Background</div> <p>Post laparoscopic cholecystectomy pain management can reduce recovery and discharge time. Non-steroidal anti-inflammatory drugs and opioids are used for this purpose.</p> </sec> <sec> <div>Objectives</div> <p>This randomized clinical trial evaluates the efficacy of diclofenac rectal suppository for the management of postoperative pain.</p> </sec> <sec> <div>Patients and Methods</div> <p>Forty four patients were randomized to receive either 100 mg diclofenac rectal suppository or placebo at the time of recovery and three hours later after laparoscopic cholecystectomy. Postoperative visual analogue pain scale (VAS, ranges 0 to 10 cm) and adverse reactions were recorded over a 24-hour period. If VAS score was &amp;#x2265; 7, 25mg, pethedin was given intravenously as a rescue analgesic.</p> </sec> <sec> <div>Results</div> <p>In both groups, VAS score was reduced in 24 hours. It was statistically lower in diclofenac group rather than placebo group in all intervals except at the time of recovery. Moreover, the mean pethedin consumption dose and the incidence of administration of postoperative rescue analgesic were statistically lower in diclofenac group. Postoperative bleeding was not statistically different between two groups.</p> </sec> <sec> <div>Conclusions</div> <p>Diclofenac rectal suppository provided simple and safe pain relief in laparoscopic cholecystectomy.</p> </sec> Cholecystectomy, Laparoscopic,Diclofenac,Analgesics, Opioid 100 110 http://annbsurg.iums.ac.ir/browse.php?a_code=A-10-31-112&slc_lang=en&sid=1 Mohammadreza Arab 1003194753284600121 1003194753284600121 No Department of Surgery, Firoozgar Hospital, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, IR Iran Hossein Saeedi Motahhar 1003194753284600122 1003194753284600122 No Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, IR Iran Abdolreza Pazouki 1003194753284600123 1003194753284600123 Yes Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, IR Iran Zeinab Tamannaie 1003194753284600124 1003194753284600124 No Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, IR Iran Babak Arabpour 1003194753284600125 1003194753284600125 No Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, IR Iran Hossein Fahimi 1003194753284600126 1003194753284600126 No Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, IR Iran