en Laparoscopic Total Gastric Vertical Plication Basic Science Basic Science Letter/Editorial Letter/Editorial <sec> <div>Dear Editor</div> <p>Golpaie et al. reported changes in lipid profile and insulin resistance in morbid obese patients following the Laparoscopic Total Gastric Vertical Plication (LTGVP), and it revealed a significant weight loss and an improvement of lipid profile and insulin resistance among morbidly obese patients (<xref ref-type=&quot;bibr&quot; rid=&quot;A4700R1&quot;>1</xref>). This method was introduced by Talebpour et al. 2007, as a new technique derived from sleeve gastrectomy for the treatment of morbid obesity and produces the restriction by a plication of the great curvature of the stomach using three lines of sutures (<xref ref-type=&quot;bibr&quot; rid=&quot;A4700R2&quot;>2</xref>). Menchaca et al. reported the experimental study of vertical gastric plication using hound dogs. It revealed that LTGVP confirmed the short-term durability and development of dense fibrous appositions of the serosal folds (<xref ref-type=&quot;bibr&quot; rid=&quot;A4700R3&quot;>3</xref>), although, additional studies are needed to identify clinical applications of this procedure. In fact, LTGVP gives equivalent short-term outcomes as vertical gastrectomy and is a reproducible and reversible technique with indications and outcomes still to be validated (<xref ref-type=&quot;bibr&quot; rid=&quot;A4700R4&quot;>4</xref>). However, there is a unique morbidity of intractable vomiting requiring re-operation due to a herniation of the suture line in this procedure. As authors described, this report needs a further evaluation in the number of the patients and long-term outcomes. Furthermore, this technique is not standardized with regards to the size of probe used as a guide for the plication, the starting point of the plication, the number of the suture line and the suture technique itself.</p> <p>LTGVP provides the preservation of stomach without resection. It is cost effective, and showed the similar outcomes compared with the vertical gastrectomy. This procedure has a possibility of new direction for the restriction of bariatric surgery. However, the evaluation of multi-center clinical trial is mandatory.</p> </sec> Bariatric Surgery,Obesity, Morbid 100 110 http://annbsurg.iums.ac.ir/browse.php?a_code=A-10-31-105&slc_lang=en&sid=1 Nobumi Tagaya 1003194753284600105 1003194753284600105 Yes First Department of Surgery, Koshigaya Hospital, Dokkyo Medical University, Tochigi, Japan